Among them, a study on MCM8 showed that the expression of MCM8 was upregulated by 2–5.2-fold in human cancers including breast cancer, non-small cell lung cancer, liver cancer, glioblastoma multiforme, and myeloblastoma, indicating that overexpression of MCM8 has extensive significance in human malignant tumors16. The gene discussed is MCM8; the disease is cancer.