CD8A and neoplasm: In the TCGA cohort (Fig. 7A), the high-risk subgroup generally had lower levels of infiltration of immune cells, especially of CD8+ T cells, neutrophils, natural killer (NK) cells, T helper (Th) cells (Tfh, Th1, and Th2 cells), tumour-infiltrating lymphocytes (TILs) and regulatory T (Treg) cells, than the low-risk subgroup.