Median baseline NfL concentrations were higher in asymptomatic mutation carriers who phenoconverted to either MBI/MCI or dementia over the next 2 years compared to those who remained asymptomatic (11.4 ± 7 pg/mL vs 6.7 ± 5 pg/mL, p = 0.002, figure 4). Here, NEFL is linked to dementia.