NEFL and early-onset autosomal dominant Alzheimer disease: Recent US Food and Drug Administration guidance on developing therapeutics for presymptomatic or early Alzheimer disease suggests that therapies might be approved under an accelerated mechanism on the basis of a biomarker that is “reasonably likely to predict clinical benefit.”39 Our data show associations between plasma NfL concentrations and subsequent functional status, which are considered inherently clinically meaningful, within 2 years of follow-up.