SERPING1 and hereditary angioedema: Currently on-demand therapies (ODT) for the treatment of C1-INH-HAE attacks are available: fresh frozen plasma, two plasma derived C1-INH (Berinert®, Cinryze®), one recombinant C1-INH (Ruconest®) and the bradykinin receptor antagonist Icatibant (Firazyr®) [23].