According to the previous meta-analysis and systematic reviews on the efficacy of Vitamin D supplementation against NAFLD [3, 29], most RCTs were carried out using cholecalciferol for vitamin D intervention, but considering our objective to assess the differential VDR FokI genotypes responses to vitamin D in the context of NAFLD, we made our interventions using calcitriol which is the immediate ligand for VDR to produce biologic effects. Here, VDR is linked to metabolic dysfunction-associated steatotic liver disease.