A second report described an infant with biallelic somatic RB1 inactivating alterations (LRG_517t1:c.T494A;p.Leu165*, LRG_517t1:c.717dup;p.Lys249*) in the absence of a germline RB1 alteration, who presented with an ectopic, intracranial, sellar-suprasellar region retinoblastoma, but also had a smaller similar-appearing pineal mass detected on imaging [23]. This evidence concerns the gene RB1 and retinoblastoma.