Compared with the NMHFS group, the MSHFS group had a higher percentage of peripheral blood circulation [167 cases (65.5%) vs 171 cases (83.5%), P < 0.001], a higher percentage of excessive sweat excretion [28 cases (11.0%) vs 55 cases (26.7%), P < 0.001], a higher proportion of preoperative tumours [61 cases (23.9%) vs 67 cases (32.5%), P = 0.040], a higher HER2-positive rate [47 cases (18.4%) vs 65 cases (31.6%), P = 0.001], and was more likely to have a history of gallstones [5 cases (2.0%) vs 16 cases (7.8%), P = 0.003]. The gene discussed is ERBB2; the disease is gallstones.