Age, ECOG score, hypertension, diabetes, cholecystitis, viral hepatitis, allergy to the first infusion of PLD, ER, PR, Ki67, baseline GGT, baseline TBIL, baseline MONO, baseline NLR, baseline PLR, baseline CEA, and baseline CA153 were not significantly different between the groups (P > 0.05, Table 3). This evidence concerns the gene ESR1 and Cholecystitis.