She received growth hormone therapy for short stature from 6 to 12 years of age, and gonadotropin releasing hormone analog therapy for central precocious puberty with menarche at 7.5 years of age (the menarchial age in Japanese girls, 12.25 ± 1.25 years) from 7 to 12 years of age. This evidence concerns the gene GH1 and central precocious puberty.