For secondary aims, 88 pregnancies in each group would yield > 80% power to detect effects equal to or smaller than those reported in prior work testing effects of lifestyle interventions on reductions in glucose, triglycerides, CRP [154], insulin, leptin [155], adiponectin [156], and blood pressure [157], taking into account estimations of site-specific clustering effects and effect modifiers (i.e., weight status, ethnicity, parity) of insulin resistance [158], and CVD risk factors [159, 160]. Here, INS is linked to Insulin resistance.