Several studies have revealed that UBE2M and UBE2F are both overexpressed in multiple types of cancers, such as hepatocellular carcinoma, lung adenocarcinoma, osteosarcoma, ovarian cancer, and squamous cell carcinoma (Table 1) [97–101], and bioinformatics analysis of The Cancer Genome Atlas (TCGA) datasets has revealed that their expression is upregulated in cancer tissues compared with normal tissues [102–104]. Here, UBE2F is linked to cancer.