PIEZO2 and Gordon syndrome: One patient with MWKS has been identified with a de novo missense mutation (p.R2686C) in PIEZO2. Mutations in PIEZO2 were also found in the phenotypically overlapping syndromes, Gordon syndrome or distal arthrogryposis, type 3 (DA3) and distal arthrogryposis, type 5 (DA5) [51].