De novo heterozygous missense PLXND1 variants were reported in three individuals with Moebius syndrome and variable dysmorphic features (including microcephaly, epicanthal folds, flat nasal bridge, micrognathia, external ear defects, dental defects, clinodactyly, and low-set thumbs) [21]. This evidence concerns the gene PLXND1 and Moebius syndrome.