The impairment in AKT signaling by high-fat diet-induced obesity resulted in FOXO1 transcription factor trap in nucleus, which caused desmosomal cadherin Dsc3 deregulation, c–Myc over-expression, as well as an increase in mitogen activation and tight junction cleavage in colon cells, consequently giving rise to colon tumorigenesis [108]. Here, MYC is linked to obesity due to melanocortin 4 receptor deficiency.