Latest researches have acknowledged a panel of immune changes associated with an adaptive immune response that are impacted by obesity, such as the elevated CD8 cytotoxic T cell reaction, shifts to Th1/Th17 T cell populations, the reduced number of regulatory T cells, which plays a significant role in additional recruiting M1 macrophages and following inflammation [119, 120].Some studies demonstrated that high-fat diet-induced obesity increases the inflammatory mediators in the intestinal mucosa. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.