LGR5 and obesity due to melanocortin 4 receptor deficiency: Other studies found no connection between the high-fat diet-induced obesity and its predominant fatty acid components with activation of inflammatory signaling (e.g., TNF-α, Infg, the NFκB or the STAT-3) in the APC l/l model mice epithelium or organoids, inflammatory cytokine (IL1, IL6, IL17) receptors in colonic Lgr5 + stem cells [77], and inflammatory cytokine (IL1, IL6, IL17) receptors in colonic Lgr5 + stem cells [80].