CYLD phosphorylation and cleavage caspase3 were detected by Western blotting, and the results further indicated that BTK inhibitors could enhance the apoptosis of non-GCB-DLBCL cells induced by rituximab through down-regulating the phosphorylation of CYLD (Fig. 5g). The gene discussed is CYLD; the disease is diffuse large B-cell lymphoma.