PIK3CA and colorectal carcinoma: EGFR signaling is able to crosstalk with the Wnt-β-catenin pathway to stimulate CRC growth and can trigger β-catenin signals via the receptor tyrosine kinase-PI3K/Akt pathway, while β-catenin can stimulate EGFR signaling via the transmembrane Frizzled receptor [2, 106].