SLC5A2 and diabetes mellitus: However, because of a compensatory increase in SGLT1-mediated transport [8], or other latent factors, complete pharmacological blockade of SGLT2 only leads to urinary excretion of 50–80 g of glucose per day (i.e., SGLT2i block < 50% of renal glucose reabsorption) in healthy individuals [4] and this level of SGLT2i-mediated glycosuria does not increase even in those with diabetes mellitus [9, 10].