Similarly, in the IMMUNED study in patients with resected stage IV melanoma with no evidence of disease, adjuvant nivolumab in combination with ipilimumab increased RFS compared with nivolumab alone [41], with this difference being even more pronounced in the BRAF-mutant population (2-year RFS of 87% versus 44% for nivolumab monotherapy, HR 0.17). Here, BRAF is linked to melanoma.