Table 5 summarizes the PPI network hub genes (five up regulated and five down regulated) that were identified in the T1D, which included EGFR, GRIN2B, GJA1, CAP2, MIF, POLR2A, PRKACA, GABARAP, TLN1 and PXN. This evidence concerns the gene POLR2A and type 1 diabetes mellitus.