PRKACA (protein kinase cAMP-activated catalytic subunit alpha), DSP (desmoplakin), hsa-mir-4257, hsa-mir-564, hsa-mir-4300, hsa-mir-5694, RGS4, FOXD1, EYA1, TFAP2A and GAB2 might be considered as a novel biomarkers associated with the development of T1D. This evidence concerns the gene PRKACA and type 1 diabetes mellitus.