ENO1 was upregulated in multiple cancers and its overexpression was involved in tumor cell proliferation and metastasis such as glioma [36], gastric [37], pancreatic [38], colorectal [39], BC [40] etc. ZNF132 expression was negatively associated with CCNE1 and ENO1 level based on the correlation analysis. Here, ENO1 is linked to central nervous system cancer.