With progression of tumor stage, the relative frequency of PIK3CA mutation increased, and tumors carrying dimutation of LRP1B + HMCN1 might much more likely to acquire PIK3CA mutations in pathological stage II, which could explain why the relative frequency of dimutation of LRP1B + HMCN1 severely decreased (yellow line) as the relative frequency of trimutation of LRP1B + HMCN1 + PIK3CA increased (dark blue line). Here, PIK3CA is linked to neoplasm.