The results above indicated that PIK3CA + HMCN1 as the marginal factor might interact with LRP1B mutation to block oncogenic progression by regulating hazardous factors such as vitronectin (VTN), which induces cancer stemness and acts as a poor prognostic factor in gastric cancer [25] [26],NTSR1, which acts as a poor prognostic marker [27], and MAPK4, which promotes tumor progression [28], as well as facilitating beneficial survival factors such as CTH, which converts cystathione derived from methionine into cysteine [29] (Fig. 4c). This evidence concerns the gene PIK3CA and gastric cancer.