RET and medullary thyroid gland carcinoma: Screening for germline RET mutations in new patients with MTC regardless of their family history is recommended and may help not only to discover de novo families, but also correctly diagnose approximately 1–7% of patients with presumed sMTC that actually have MEN2 [1, 14, 19], such as patients with S409Y, M918V, and C609R, C634W in the present series.