KLF5 and squamous cell intraepithelial neoplasia: In addition, Marrero-rodriguez et al. found that KLF5 showed a gradual up-regulation trend in normal tissues, low-grade intraepithelial lesions, intraepithelial squamous lesions and CC samples, showing the up-regulation of KLF5 expression plays a certain role in the case and development of cervical cancer [18].