In this context, we built an NGS custom pan-cancer panel containing 16 high and moderate penetrance genes previously associated with hereditary cancer syndromes (APC, BRCA1, BRCA2, CDH1, CDKN2A, CHEK2, MSH2, MSH6, MUTYH, PTEN, RB1, RET, TP53, VHL, XPA and XPC) [10, 11]. Here, PTEN is linked to Inherited cancer-predisposing syndrome.