In a sharp contrast to this observation, our data from the present study not only showed induction of potent autologous neutralizing antibodies in rabbits by 1PGE-THIVC SOSIP that was prepared from env sequence obtained from the broadly cross neutralizing plasma at the late disease stage, but also demonstrated comparable specificity to 1PGE-THIVC SOSIP trimers of neutralizing antibodies induced in rabbits and those elicited in natural infection in human elite neutralizer from whom 1PGE-THIVC primary sequence was obtained [32]. Here, ERVW-1 is linked to infection.