Digoxin targets the “Pancreatic secretion” and “Protein digestion and absorption” through 8 genes: ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3 and FXYD2. ATP1A2 is over-expressed in OSF and under-expressed in Dupuytren’s Disease while ATP1B1 is over-expressed in Dupuytren’s and FXYD2 over-expressed in Polycystic Kidney Disease. This evidence concerns the gene ATP1A3 and polycystic kidney disease.