When NSCs and EVs were intracerebroventricularly (ICV) delivered in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), both NSCs and EVs induced a significant amelioration of neurological deficits, and transplanted NSCs transferred mitochondria to mononuclear phagocytes in vivo. This evidence concerns the gene MOG and experimental autoimmune encephalomyelitis.