MAPK3 and cardiac hypertrophy: 2000). ERK1/2 has been shown to be activated in cultured neonatal rat cardiomyocytes via agonist stimulation and cell stretching (Post et al. 1996; Saucerman et al. 2019). It has been demonstrated that autophosphorylation of ERK1/2 on Thr188 directed ERK1/2 to phosphorylate nuclear targets that are known to cause cardiac hypertrophy (Lorenz et al. 2009; Luan et al. 2015). Several studies have reported that Chinese herbal extracts can improve myocardial function under the stimulation of pathological factors (Sun et al. 2016).