Correspondingly, restraining the TNFα/NF-κB pathway in microglia can effectively reduce microglial activation and prevent diet-induced obesity (Valdearcos et al., 2017), and blocking the TNFα/NF-κB pathway in POMC neurons can also reduce the diet-induced obesity. This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.