Interestingly, Sirtuin 1 (SIRT1), a transcriptional target of TAp63 (Su et al., 2012), plays a sex-specific role in POMC neurons to prevent obesity in females but not in males (Ramadori et al., 2010), similar to effects of TAp63. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.