Alternatively, a combinational genetic manipulation targeting subpopulation of astrocytes that express 10-formyltetrahydrofolate dehydrogenase (Aldh1l1) (Srinivasan et al., 2016) or glutamate aspartate transporter (Glast) (Mori et al., 2006), might be essential for the complete understanding of astrocytes function in the context of obesity and metabolic disorders. This evidence concerns the gene ALDH1L1 and Other metabolic disease.