Importantly, clamping the activity level of PVH CRH neurons either at high or low levels, which render these neurons not responsive to either stressors or nutritional challenges, mimicking HFD effects on obesity development (Zhu et al., 2020), which illustrates a potential importance of dynamic responses of PVH CRH neurons to environmental or nutritional challenges in HFD-induced obesity. The gene discussed is CRH; the disease is Obesity.