In particular, double knockout of synapse-associated protein 90/postsynaptic density-95-associated protein-3 (Sapap3), a key gene involved in anxiety-like behaviors, and Mc4r, one of the most frequent obesogenic genes in humans, completely rescues anxiety-like behaviors seen in Sapap3 knockouts and obesity in Mc4r knockouts (Xu et al., 2013), demonstrating an intimate interaction between the two seemingly unrelated genes. Here, DLGAP3 is linked to Anxiety.