Furthermore, fibroblast growth factor 21 (FGF21) was reported to be elevated in DMD muscles [104] and to negatively regulate bone homeostasis by potentiating peroxisome proliferator-activated receptor gamma (PPAR-γ) activity, resulting in adipogenesis stimulation and osteogenesis inhibition from bone marrow stem cells. The gene discussed is FGF21; the disease is Duchenne muscular dystrophy.