NOS1 and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Importantly, in addition to intracellular signaling, cell-to-cell communication is also affected in dystrophin deficiency, as shown, e.g., by vasoconstriction related to nNOS downregulation and displacement from the sarcolemma [121–124], abrogated satellite cell activation due to dysregulated Notch signaling [199], or changes in the production of myokines that affect the bone [71, 93, 98, 104].