Compounds such as birinapant, LCL161 and Debio 1143 (AT-406) exhibit cytotoxic effects in head and neck squamous cell carcinoma cells with genomic amplification of Fas-associated Death Domain (FADD), cIAP1 or cIAP2 and in inflammatory breast cancer cells overexpressing XIAP, as well as in human hepatocellular carcinoma cell lines or in MDA-MB-231 breast cancer xenograft models [158]. The gene discussed is FADD; the disease is breast cancer.