For example, mutations in CYLD, USP8, A20 and the von Hippel-Lindau tumor suppressor (VHL; elongin-cullin-2-VHL (CRL2VHL) E3 ubiquitin ligase) are related to cylindromatosis, Cushing disease, autoinflammatory syndrome and heritable cancer syndrome, respectively. Here, VHL is linked to autoinflammatory syndrome.