CP and COVID-19: These are commentaries that supported clinical use and evaluation of CP for COVID-19 treatment based on the unique immunomodulatory properties of CP and historical and current data for its safety and efficacy against coronaviruses including SARS-CoV-2 but suggested limitations, future clinical investigations, and a variety of aspects to be considered for the optimal use of CP for COVID-19 including CP donor selection, CP collection and testing, manufacturing turnaround time, cost and the logistics of storage, distribution, treatment population, and administration timing and dosing.