It is noteworthy that 1 systematic review and meta-analysis was on the safety and efficacy of CP therapy for other severe respiratory viral infections to provide indirect evidence for CP therapy for COVID-19 [206], and another 2 systematic reviews and meta-analyses were on completed and ongoing clinical studies on the safety and efficacy of CP or hyperimmune immunoglobulin transfusion in the treatment of COVID-19 [207,208]. The gene discussed is CP; the disease is COVID-19.