SIRT1 and stroke disorder: Although we did not measure the oxidative capacity of each fiber type, an inverse relationship exists between skeletal muscle fiber area and oxidative capacity.56 Recent gain of function data in the mouse suggest that the amelioration of skeletal muscle atrophy is a result of SIRT1 signaling,57 which is activated by RESV.20 Although RESV did not improve aerobic capacity on a poststroke maximal exercise test, it led to changes in skeletal muscle congruent with behavioral benefits for stroke-affected muscle and, thus, warrants future investigation.