In addition, the ACE/AngII/AT1R axis also has a potent inflammatory and pro-fibrotic role and triggers important adverse reactions such as myocardial hypertrophy and dysfunction, endothelial dysfunction, obesity-associated hypertension, interstitial fibrosis, and oxidative stress [38, 39, 107, 108]. The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.