IFNA1 and metastatic neoplasm: Given that ablation of MAMs or inhibition of MAM recruitment suppressed metastatic growth in multiple models (Lu & Kang, 2009;Nielsenet al., 2016;Qianet al., 2011;Qianet al., 2009), it is plausible that activation of IFN signaling promotes the pro-metastatic activity of MAMs, which may therefore limit the favorable effects of IFN-alpha treatment for patients of metastatic diseases (Eggermontet al., 2014).