Second, according to the results of the GSEA, COPB2 may also influence the progression of HCC through other signaling pathways other than the mTOR signaling pathway; however, the current research on the relationship between COPB2 and HCC is in its infancy, and a lot of work is needed to explore whether COPB2 can affect HCC through other pathways in subsequent studies. This evidence concerns the gene MTOR and hepatocellular carcinoma.