KEGG pathway analysis indicated that the Xiaochaihu decoction which exerted its pharmacological effects on acute pancreatitis was closely associated with pathways in cancers (fold enrichment = 5.4, P < 0.001), TNF signaling way (fold enrichment = 12.2, P < 0.001), PI3K-Akt signaling pathway (fold enrichment = 3.7, P < 0.001), influenza A (fold enrichment = 7.1, P < 0.001), Chagas disease (fold enrichment = 11.0, P < 0.001), and MAPK signaling pathway (fold enrichment = 4.5, P < 0.001) which were involved with MAPK3, TP53, TNF, and so on (Figure 5). The gene discussed is TNF; the disease is acute pancreatitis.