Hence, this study evaluated the expression of normally downregulated biomarkers (miR-21, miR-155, miR-182, miR-200, p53 gene, Ki67, and squamous cell carcinoma antigen 1 [SCCA1]) and normally upregulated biomarkers (miR-let-7b, miR-125b, miR-143, miR-145, and CD4+ T-cells) in individuals with single through ternary viral infections and those without the targeted viral infections (EBV, HPV and HSV-2). The gene discussed is MKI67; the disease is viral infectious disease.