This study estimated the expression of normally downregulated biomarkers (miR-21, miR-155, miR-182, miR-200, p53 gene, Ki67 and SCCA1) and normally upregulated biomarkers (miR-let-7b, miR-125b, miR-143, miR-145 and CD4+ T-cells) in viral mono-infection through tri-infection.6 Since overexpression of oncomirs and underexpression of tumour suppressors are usually found in all cancers, especially cervical cancer,17,18,19,20 this study compared the level of biomarkers in groups 1 to 8 in a bid to identify the biomarkers that are severely affected by viral co-infection. The gene discussed is CD4; the disease is cervical cancer.