Screening for CD is usually done by serologic testing, which includes the estimation of Celiac specific antibodies as anti-endomysial antibodies (EMAs), anti-tissue transglutaminase (anti-tTG) antibodies and anti-deamidated gliadin derived peptides. Anti-tTG antibody titers are the most preferred initial screening test for the CD because of high sensitivity and specificity [5,6]. Here, TGM2 is linked to Cowden disease.