Barker et al. showed that 48 of the 49 symptomatic children with anti-tTG antibody titers ≥ 100 U/ml (five times the normal cut-off) had Marsh grading of at least grade II enteropathy with a sensitivity and specificity of 98% and 97.2%, respectively [19]. Here, TGM2 is linked to Abnormal intestine morphology.