STAT3 and hydrops fetalis: We further found that the phosphorylation of STAT3 in the myocardial tissue of TAC mice was significantly increased and IL-6/gp130/STAT3 inhibition has a cardioprotective effect, all of which indicated that the inflammatory signaling pathway of the IL-6/gp130/STAT3 axis might play a crucial role in the cardiac remodeling and HF.