In this study, we investigated the effect of electroacupuncture on the phosphorylation level of IRS-1 in ZDF rats and observed whether electroacupuncture can promote the uptake of skeletal muscle glucose by regulating the phosphorylation of skeletal muscle IRS-1, which provides evidence for the mechanism of electro-acupuncture treatment in type 2 diabetes. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.