IL4 and Increased total eosinophil count: Further studies by Ai et al and Wang et al found that XGND can significantly reduce the concentration of IgE, IL-4, IL-5, LTE4, and tryptase in the serum and decrease eosinophilia in the nasal mucosa of AR guinea pigs and rats, by downregulating PLCE1-PKC-NF-κB signaling pathway, correcting Th1/Th2 immune imbalance, and thereby inhibiting the release of inflammatory mediators, to alleviate allergic symptoms in AR guinea pigs and rats [21, 22].