LGR5 and colorectal cancer: To date, observations from breast, prostate and squamous cell carcinoma indicate a particularly high degree of plasticity in the intermediate EMT states, which is reflected by efficient metastatic dissemination and outgrowth.48,118 Notably, in a mouse model of colorectal cancer, the majority of disseminated cells in the circulation did not express Lgr5, a marker of cancer stem cells, but formed distant metastases in which Lgr5-positive cells were subsequently detected.