Previous studies have revealed that the anti-tumorigenic effects of andrographis in CRC cells were associated with the suppression of the TLR4/NF-κB/MMP-9/NADPH Oxidase and Src/MAPKs/AP-1 axis and through enhancement of the expression of the BAX protein37, 40, 41. Here, MMP9 is linked to colorectal carcinoma.