A systemic review demonstrated the elevation of TGF-β among CFS patients had significant differences between cases and control58, while up to thirteen cytokines (including: CCL11, CXCL1, CXCL10, IFN-γ, IL-4, IL-5, IL-7, IL-12, IL-13, IL-17, leptin, G-CSF, and GM-CSF ) were recognized among CFS patients and had a statistically significant upward linear trend that correlated with CFS severity59. The gene discussed is IL4; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.