POMC and myalgic encephalomeyelitis/chronic fatigue syndrome: Hypocortisolemia42, loss of the diurnal peak of adrenocorticotropic hormone(ACTH) and cortisol levels43; blunted responsiveness of HPA axis under the challenge test44; recent immune-inflammatory, oxidative, and nitrosative stress (O&NS) pathways45 were well reported among CFS.