Importantly, survival in lung adenocarcinoma (LUAD) did not significantly segregate by GPX4, TXNRD1 or combined GPX4 and TXNRD1 expression (Supplementary Fig. 9h–j) suggesting a function for redox pathway plasticity in determining patient outcome to be a unique feature of SCLC. The gene discussed is TXNRD1; the disease is lung adenocarcinoma.