Strikingly, upon silencing of the ER-resident ether lipid synthesis enzyme 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) or AGPAT3, non-NE SCLC cells were indeed less sensitive to ferroptosis (Fig. 4g, h; Supplementary Fig. 5m, n). This evidence concerns the gene AGPAT2 and small cell lung carcinoma.