In accordance with these data, we identify non-NE SCLC to be exquisitely ferroptosis sensitive and to express EMT signature genes, such as vimentin. Key enzymes generating the PUFA lipid target pool for lipid peroxidation are ACSL4 and LPCAT3 which generate AA-CoA for lysophospholipid acylation, respectively. Here, ACSL4 is linked to small cell lung carcinoma.