Interestingly, while TrxR1 and TrxR2 were upregulated only in human NE SCLC cells, expression of TXNIP was consistently increased in human and murine NE cells suggesting NE SCLC cells to also experience a limited availability TRX-mediated anti-oxidant defense (Fig. 5b; Supplementary Fig. 7g). The gene discussed is TXNIP; the disease is small cell lung carcinoma.