Therefore, to validate ferroptosis response segregation by NE and non-NE differentiation in an independent and genetically-defined experimental cellular set-up, we made use of SCLC cells derived from the RP mouse model in which Adenoviral-Cre-mediated deletion of Rb1 and Tp53 in the lung gives rise to NE ASCL1+ SCLC as compared to cells derived from the RPM mouse model in which additional expression of cMycT58A leads to largely non-NE differentiated tumors36. Here, RB1 is linked to small cell lung carcinoma.