LCN2 and cancer: Since it is suggested that gastrointestinal malabsorption may play a role in energy balance during cancer cachexia, we analyzed fecal lipid, protein, and protease concentrations and did not detect changes during cachexia nor genotype-specific alterations, except for an increase in fecal lipids of Lcn2-KO mice at the final 5 days of the study (days 7–11), although this may be due to increased food intake as these animals were not pair-fed (Supplementary Fig. 3Q–U).