We also monitored blood glucose of WT and Lcn2-KO mice and observed a significant increase in Lcn2-KO tumor-bearing mice compared to WT at the end of the study, likely due to the increased food consumption of Lcn2-KO tumor-bearing mice, as WT and Lcn2-KO sham controls remained similar throughout the study (Supplementary Fig. 3V–X). Here, LCN2 is linked to neoplasm.