To examine whether restoration of Lcn2 expression in the bone marrow compartment influences energy balance during pancreatic cancer cachexia, we engrafted WT bone marrow into Lcn2-KO mice, allowed transplanted animals to recover for 8 weeks, then orthotopically implanted pancreatic cancer cells and monitored feeding behavior. This evidence concerns the gene LCN2 and familial pancreatic carcinoma.