Since several inflammatory mediators are shown to regulate LCN2 levels in various pathologies, we demonstrate that mice devoid of Il-6 and Myd88, two inflammatory pathways known to mediate host metabolism during cachexia6,21, have reduced circulating LCN2 levels, demonstrating LCN2 is an inflammation-induced protein during cancer cachexia. The gene discussed is LCN2; the disease is Cachexia.