Following infection, ∆Cyto+TM behaved similarly to WT US9, ∆Ig showed partial impairment in MICA*008 downregulation, and 8SP was greatly impaired in MICA*008 downregulation, to the extent that MICA*008 levels in 8SP-expressing cells approached those in EV control cells. This evidence concerns the gene RPS16 and infection.