We noted that among the brain tissues with the highest usage of the intron-3 retaining transcript of APOE are those that show selective vulnerability for neurodegeneration, namely the hippocampus in the context of Alzheimer’s disease, the substantia nigra in the context of Parkinson’s disease and the spinal cord in the context of amyotrophic lateral sclerosis (pairwise comparisons between brain regions shown in Supplementary Table 6). Here, APOE is linked to amyotrophic lateral sclerosis.