APOE and early-onset autosomal dominant Alzheimer disease: Given the high CNCR density of APOE, its importance as a disease locus for Alzheimer’s disease and other neurodegenerative diseases20 and the long-standing interest in its lineage specificity8,21 (specifically the differences in the ɛ4 allele between humans and non-human primates1), we chose to focus on this gene to further validate our annotation.