APOE and early-onset autosomal dominant Alzheimer disease: Taken together, these findings could suggest that usage of the intron-3 retaining transcript may be regulated by APOE-ε4 status and may be involved in mediating the effect of APOE genotype, supporting a role for the presence of this lncRNA in disease risk and progression, although it is also feasible that Alzheimer’s disease pathology could drive intron-3 retention