FRS2 and neoplasm: Flow cytometry and ELISPOT analyses indicated that CC-SnT-TRP2 OMVs elicited a strong increase in the numbers of IFNγ+ cytotoxic T lymphocytes (Fig. 4f and Supplementary Fig. 16) and IFNγ production (Fig. 4g, h), confirming that OMVs displaying a specific tumor antigen can induce a strong adaptive immune response.