These alterations are also observed in ALS/FTD caused by aggregation of TDP-43 in non-fibrillary oligomeric amyloid-like aggregates56 and seem related with the interference of the proteins with the nucleocytoplasmic system, e.g., microtubules in the case of Tau54 or the nuclear transport machinery in the case of TDP-4356, resulting in the invaginations. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.