Moreover, TRIP12 knockdown also sensitised HCT15 and HT29 cells, two additional colorectal cancer cell lines that harbour a wildtype FBW7 allele, to Taxol, whereas SW837 and SNU175 cells, which harbour a somatic deletion of FBW7 (L403fs) and a missense mutation (R465C), respectively, were largely resistant to Taxol regardless of TRIP12 deletion (Fig. 3g). Here, TRIP12 is linked to colorectal cancer.