MCL1 and malignant colon neoplasm: Inhibition of FBW7 expression with either siRNA in HEK293T cells, or genetic knockout via CRISPR/Cas9 in HCT116 colon cancer cells, completely rescued MCL1 levels in TRIP12-silenced and TRIP12-knockout cells, respectively (Fig. 3d and Supplementary Fig. 3b).